Efficient organocatalytic enantioselective synthesis of spironitrocyclopropanes

28 Nov 2012

This communication is HOT as recommended by the referees, and is free to access for 4 weeks

Researchers from Taiwan have developed an efficient organocatalytic enantioselective synthesis of spironitrocyclopropanes.

In this HOT communication Wenwei Lin and co-workers from National Taiwan Normal University describe the development of an efficient asymmetric pathway for the preparation of spironitrocyclopropanes from 2-arylidene-1,3-indandiones and bromonitroalkanes, catalysed by cinchona-derived bifunctional organocatalysts.

Lin et al. report reaction conditions which allow almost perfect diastereocontrol as well as outstanding enantiocontrol. As nitrocyclopropanes are found in various biologically active natural products and important precursors of bio-relevant cyclopropylamines this new method fills a real synthetic need.

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An efficient organocatalytic enantioselective synthesis of spironitrocyclopropanes
Utpal Das, Yi-Ling Tsai and Wenwei Lin
DOI: 10.1039/C2OB26943K